Increased thalamic resting-state connectivity as a core driver of LSD-induced hallucinations
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(12):14 Acta Psychiatr Scand. 2017 23-Feb;():. 10.1111/acps.12818What this means for my practice?
LSD induced globally increased thalamocortical rFC compared to placebo. The subjective drug effect ratings of 'visionary restructuralization' and 'auditory alterations' significantly correlated with rFC measures between the thalamus and the right fusiform gyrus and insula. These findings suggest that hallucinogenic drug effects may be provoked by facilitations of cortical excitability via thalamocortical interactions. Overall, these findings provide implications for understanding the mechanism of action of hallucinogenic drugs. The results are limited by the small sample size, the absence of dose-response data and that ratings on subjective drug effects did not correspond to the duration of the fMRI scan exclusively.
Study Summary
Twenty healthy subjects underwent a double-blind, randomized placebo-controlled, crossover design to test the effects of LSD on the thalamocortical system. Subjects completed fMRI assessments and whole brain thalamic functional connectivity was measured with ROI-to-ROI and ROI-to-voxel approaches. LSD significantly increased thalamic functional connectivity to various cortical regions. The thalamic FC changes between the thalamus and the right fusiform gyrus and insula correlated significantly with subjective auditory and visual drug effects.
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