Increased thalamic resting-state connectivity as a core driver of LSD-induced hallucinations .
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Increased thalamic resting-state connectivity as a core driver of LSD-induced hallucinations
Acta Psychiatr Scand. 2017 23-Feb;():. 10.1111/acps.12818Twenty healthy subjects underwent a double-blind, randomized placebo-controlled, crossover design to test the effects of LSD on the thalamocortical system. Subjects completed fMRI assessments and whole brain thalamic functional connectivity was measured with ROI-to-ROI and ROI-to-voxel approaches. LSD significantly increased thalamic functional connectivity to various cortical regions. The thalamic FC changes between the thalamus and the right fusiform gyrus and insula correlated significantly with subjective auditory and visual drug effects.
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