Implications for psychedelic-assisted psychotherapy: fMRI study with psilocybin. .
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Implications for psychedelic-assisted psychotherapy: functional magnetic resonance imaging study with psilocybin
Br J Psychiatry. 2012 23-Feb;():. 10.1192/bjp.bp.111.103309Ten healthy subjects with previous psychedelic experience underwent a randomized, placebo-controlled, cross-over study to test the effects of psilocybin on subjective and neural responses to positive autobiographical memories. Subjects received both psilocybin and a placebo seven days apart, and completed two fMRI scans while viewing two sets of autobiographical memory cues. Responses to autobiographical memories were measured through a recollection period, where subjects re-experienced the memory cue. Both the psilocybin and placebo had robust activations in the limbic/striatal regions in the early phase and the medial prefrontal cortex in the late phase. Psilocybin induced more visual and sensory cortical activations in the late phase.
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