Implications for psychedelic-assisted psychotherapy: functional magnetic resonance imaging study with psilocybin
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(11):8 Br J Psychiatry. 2012 23-Feb;():. 10.1192/bjp.bp.111.103309What this means for my practice?
Psilocybin induced greater visual/sensory cortical activations in the late phase. These regions of activations included the bilateral auditory cortex, somatosensory cortex, superior parietal cortex, left visual association regions and the occipital pole. Memory vividness and visual imagery ratings were also higher under psilocybin. There was a significant positive correlation between vividness and subjective well-being. These findings indicate that psilocybin enhances autobiographical recollection which provides implications for the use of psilocybin in psychotherapy. These results are limited by the small sample size and the prior assumption of the positive value of these drugs by the participants, since they all had prior experience.
Study Summary
Ten healthy subjects with previous psychedelic experience underwent a randomized, placebo-controlled, cross-over study to test the effects of psilocybin on subjective and neural responses to positive autobiographical memories. Subjects received both psilocybin and a placebo seven days apart, and completed two fMRI scans while viewing two sets of autobiographical memory cues. Responses to autobiographical memories were measured through a recollection period, where subjects re-experienced the memory cue. Both the psilocybin and placebo had robust activations in the limbic/striatal regions in the early phase and the medial prefrontal cortex in the late phase. Psilocybin induced more visual and sensory cortical activations in the late phase.
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