Using psilocybin to investigate the relationship between attention, working memory, and the serotonin 1A and 2A receptors
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(11):9 J Cogn Neurosci. 2005 23-Feb;():. 10.1162/089892905774597191What this means for my practice?
Psilocybin impairs multiple-object tracking (attention), but not spatial working memory. A previous correlation between performance on attentional tracking and spatial working memory tasks that was present in the placebo condition was eliminated under psilocybin. These findings indicate that psilocybin induces a functional dissociation between attention and working memory processes. The finding that ketanserin did not block the impairment effect on multiple-object tracking suggests that 5-HT2A receptors do not play a direct role in attentional processes, and instead provides evidence for the role of 5-HT1A receptors. These results are limited by the small sample size, and that some participants had prior psilocybin experience.
Study Summary
Eight healthy subjects underwent a double-blind, placebo-controlled study to investigate the relationship between attention, working memory, serotonin (5-HT) receptors, and prefrontal cortex activity, using psilocybin. The subjects were tested on a multiple-object tracking task and spatial working memory task under four conditions: placebo, psilocybin (215 microg/kg), ketanserin (5-HT2A receptor antagonist), and both psilocybin and ketanserin. Psilocybin induced a significant reduction in attentional tracking ability, but had no significant effect on spatial working memory. Pretreatment with ketanserin did not affect the impact of psilocybin on attentional performance.
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