Investigating the relationship between attention, working memory, and serotonin receptors. .
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Using psilocybin to investigate the relationship between attention, working memory, and the serotonin 1A and 2A receptors
J Cogn Neurosci. 2005 23-Feb;():. 10.1162/089892905774597191Eight healthy subjects underwent a double-blind, placebo-controlled study to investigate the relationship between attention, working memory, serotonin (5-HT) receptors, and prefrontal cortex activity, using psilocybin. The subjects were tested on a multiple-object tracking task and spatial working memory task under four conditions: placebo, psilocybin (215 microg/kg), ketanserin (5-HT2A receptor antagonist), and both psilocybin and ketanserin. Psilocybin induced a significant reduction in attentional tracking ability, but had no significant effect on spatial working memory. Pretreatment with ketanserin did not affect the impact of psilocybin on attentional performance.
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