Effects of low dose ibogaine on subjective mood state and psychological performance
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(12):69 J Ethnopharmacol. 2016 23-Feb;():. 10.1016/j.jep.2016.05.022What this means for my practice?
This study did not identify any stimulant effects after a single 20 mg doses of ibogaine. Some evidence pointed to the potentially modulating effect of active moiety concentrations on selective attention abilities, although future research is needed to substantiate this relationship. Future studies should also aim to include a placebo arm, a larger sample size, and ideally a range of ibogaine doses.
Study Summary
Twenty-one healthy participants were included in this randomized, double-blind, placebo-controlled study evaluating the effect of ibogaine on psychological variables reflecting subjective mood state and a range of cognitive functions. Participants received a single 20mg Ibogaine dose following pretreatment with either paroxetine or placebo. Blood plasma concentrations and active moiety of ibogaine and noribogaine were analyzed using liquid chromatography–mass spectrometry and psychological performance was measured using a computerized battery consisting of six mood scales and eight cognitive tests measuring basic visuomotor performance and inhibitory control. Results show that ibogaine had minimal influence on psychological tests and mood ratings.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
Are you affiliated with one of our partner associations?
Click here to gain complimentary access as part your association member benefits!
0 of 4 monthly FREE articles unlocked
