Acute LSD effects on response inhibition neural networks
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OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(12):68 Psychol Med. 2018 23-Feb;():. 10.1017/S0033291717002914Study Summary
In this double-blind, randomized, placebo-controlled, cross-over study, LSD (100 μg) and placebo were administered to 18 healthy subjects with a washout period of 7 days in between sessions. Response inhibition was assessed using a functional magnetic resonance imaging Go/No-Go task. LSD-induced visual hallucinations were measured using the 5 Dimensions of Altered States of Consciousness (5D-ASC) questionnaire. Results demonstrate that 5-HT2AR activation by LSD led to deficits in inhibitory processing mediated via reduced parahippocampal–prefrontal activation. LSD produced significantly higher scores than placebo for cognitive impairments and visual hallucination as indexed by impaired control and cognition.
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