Qu'est-ce que cela signifie pour ma pratique ?

Busprione reduced the psilocybin-induced VR subscale scores for elementary and complex visual hallucinations. Though at a trend level, buspirone reduced OB subscale scores of derealisation and depersonalisation phenomena, changes in the sense of time, and basic emotions ranging from heightened mood to euphoria and mania-like experiences. These findings suggest that buspirone, through 5-HT1A receptor activation, reduces psilocybin-induced "excitatory" phenomena and visual hallucinations. The absence of effect of ergotamine could have been due to low bioavailability or a lower efficacy in transducing to the 5-HT1A/2A receptor sites. Overall, these findings highlight the important role of 5-HT1A receptors in psilocybin-induced symptoms and provide implications for treating symptoms in schizophrenia and Parkinson's disease using 5-HT1A agonists.