Effect of Leukocyte-Reduced Platelet-Rich Plasma On Synovial Fluid Biomarkers After Pilon Fractures .
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A prospective randomized double-blind clinical trial to assess the effects of leukocyte-reduced platelet-rich plasma on pro-inflammatory, degradative, and anabolic biomarkers after closed pilon fractures.
J Orthop Res . 2022 Apr;40(4):925-932Eleven patients undergoing two-staged open reduction and internal fixation (ORIF) of an isolated pilon fracture were randomized to receive either 5ml of either autogenous leukocyte-reduce platelet-rich plasma (PRP) (n=5) or sterile 0.9% saline (n=6). The primary outcomes of this trial were to assess the number of post-traumatic osteoarthritis (PTOA)-related pro-inflammatory degradative biomarkers and anabolic biomarkers during the initial post-injury time period. The results of this trial illustrated that one intra-articular injection of leukocyte-reduced PRP is associated with anti-inflammatory, anti-degradative, and anabolic responses compared with the saline control. No adverse events of complications were reported.
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