Autologous Chondrocyte Implantation vs Microfracture for the Treatment of Articular Cartilage Defect .
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Costal Chondrocyte-Derived Pellet-Type Autologous Chondrocyte Implantation Versus Microfracture for the Treatment of Articular Cartilage Defects: A 5-Year Follow-up of a Prospective Randomized Trial.
Am J Sports Med . 2024 Feb;52(2):362-367. doi: 10.1177/03635465231222797.Twenty-five patients with knee articular cartilage defects were randomized to receive either CCP-ACI (n=16) or MFx (n=9). The primary outcome was the MOCART score, assessing cartilage repair via MRI. Secondary outcomes included the Lysholm score, International Knee Documentation Committee (IKDC) score, Knee injury and Osteoarthritis Outcome Score (KOOS), and visual analog scale (VAS) for pain. Outcomes were evaluated up to 5 years post-procedure. Overall, the study found CCP-ACI to be significantly more effective in improving structural repair and clinical outcomes, as evidenced by superior MOCART, Lysholm, and KOOS scores at 5 years compared to MFx. These results suggest that CCP-ACI may offer a more durable cartilage repair method than MFx for patients with knee cartilage defects.
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