Platelet-Rich Plasma Injection After Anterior Cruciate Ligament Reconstruction
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Intra-Articular Platelet-Rich Plasma Injection After Anterior Cruciate Ligament Reconstruction: A Randomized Clinical Trial.
JAMA Netw Open . 2024 May 1;7(5):e2410134. doi: 10.1001/jamanetworkopen.2024.10134.One hundred twenty patients with anterior cruciate ligament (ACL) injuries were randomized to receive either postoperative intra-articular PRP injection (n=60) or no injection (control group; n=60) following ACL reconstruction. The primary outcome was the mean Knee Injury and Osteoarthritis Outcome Score (KOOS4) at 12 months postoperatively. Secondary outcomes included patient-reported outcomes, graft maturity (via MRI), and physical examinations conducted at 3, 6, and 12 months. Overall, the results indicated no statistically significant improvement in knee function or symptoms in the PRP group at 12 months. At 6 months, the PRP group showed a temporary improvement in the KOOS sports and recreation score and graft maturity.
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