Ten year follow-up of a randomized trial of autologous chondrocyte implantation versus alternative forms of surgical cartilage management in the knee.

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

390 patients with symptomatic knee cartilage defects following unsuccessful previous surgical treatment were randomized to receive autologous chondrocyte implantation (ACI) or alternative surgical cartilage management. The primary outcome of interest was knee function, measured using the patient-reported Lysholm knee score. Secondary outcomes included International Knee Documentation Committee (IKDC) scores, Cincinnati knee scores, patient satisfaction, health-related quality of life, treatment failure, and serious adverse events. Outcomes were assessed annually for up to 10 years. Overall, the results revealed that ACI provided significantly better long-term knee function than alternative surgical treatments, although treatment failure rates were comparable. Previous marrow stimulation did not appear to negatively affect outcomes following ACI. These findings suggested that ACI offered durable functional benefits and remained a potential revision treatment for patients with persistent symptoms following previous cartilage surgery.