Ten year follow-up of a randomized trial of autologous chondrocyte implantation versus alternative forms of surgical cartilage management in the knee.

Este estudio ha sido identificado como potencialmente de alto impacto. La métrica de alto impacto de OE, basada en la inteligencia artificial, estima la influencia que puede tener un artículo integrando señales procedentes tanto de la revista en la que se publica como del contenido científico del propio artículo. Desarrollado mediante el procesamiento del lenguaje natural más avanzado, el modelo de Alto Impacto de OE predice con mayor precisión el futuro rendimiento de las citas de un estudio que el factor de impacto de la revista por sí solo. Esto permite reconocer antes las investigaciones clínicamente significativas y ayuda a los lectores a centrarse en los artículos con más probabilidades de configurar la práctica futura.

Resumen del estudio

390 patients with symptomatic knee cartilage defects following unsuccessful previous surgical treatment were randomized to receive autologous chondrocyte implantation (ACI) or alternative surgical cartilage management. The primary outcome of interest was knee function, measured using the patient-reported Lysholm knee score. Secondary outcomes included International Knee Documentation Committee (IKDC) scores, Cincinnati knee scores, patient satisfaction, health-related quality of life, treatment failure, and serious adverse events. Outcomes were assessed annually for up to 10 years. Overall, the results revealed that ACI provided significantly better long-term knee function than alternative surgical treatments, although treatment failure rates were comparable. Previous marrow stimulation did not appear to negatively affect outcomes following ACI. These findings suggested that ACI offered durable functional benefits and remained a potential revision treatment for patients with persistent symptoms following previous cartilage surgery.