Atelocollagen vs. Prolotherapy in Partial-Thickness Supraspinatus Tears: .
Atelocollagen vs. Prolotherapy in Partial-Thickness Supraspinatus Tears: A Prospective Randomized Controlled Trial with MRI-Confirmed Outcomes.
Pain Physician . 2025 Jul;28(4):299-306.Thirty-four patients with partial-thickness supraspinatus tears were randomized to ultrasound-guided prolotherapy with 20% dextrose (n=17) or atelocollagen injections (n=17), each delivered in three weekly sessions. The primary outcome was change in pain (VAS) to 3 months. Secondary outcomes were K-SPADI and SCSS at 1 and 3 months, and MRI-based changes in tear status from baseline to 3 months. Overall, the results of the study revealed greater 3-month pain reduction with atelocollagen and superior structural healing on MRI (improvement in 26.7% vs 0%; fewer aggravations) with no between-group difference in functional gains; no complications were reported. These findings suggest atelocollagen confers added structural benefit beyond symptomatic improvement observed with both injections.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
0 of 4 monthly FREE articles unlocked
