Alterations in responses to LSD associated with chronic administration of antidepressents .
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Alterations in responses to LSD in humans associated with chronic administration of tricyclic antidepressants, monoamine oxidase inhibitors or lithium
Behav Brain Res. 1996 11-Apr;():. 10.1016/0166-4328(96)00102-7In this retrospective cohort study, 10 patients who used LSD during a period of chronic (3 weeks or longer) antidepressant administration were asked to recall the effects of hallucinogens while on, and when not on antidepressants. A semi-structured interview with a standard questionnaire regarding the effects of LSD was used for all patients. Chronic use of tricyclic antidepressants and lithium was associated with increased responses to LSD, while patients with chronic monoamine oxidase (MAO) inhibitors reported subjective decreases in LSD effects.
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