Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(14):13 J Psychopharmacol. 2011 23-Feb;():. 10.1177/0269881110382466What this means for my practice?
Experimental data from 227 psilocybin administrations demonstrate safety and tolerability both acutely and long-term. Acute adverse reactions and transient emotional instability are the biggest concerns when administering psilocybin. These effects were positively alleviated through strong interpersonal support and the strong control of environmental conditions. This indicates that psilocybin administration is well-tolerated in healthy subjects and future studies are warranted. Limitations include poor generalizability of the sample and sample self-selection bias.
Study Summary
A meta-analysis was completed to analyze the acute, short- and long-term subjective effects of psilocybin in healthy humans. Raw data was pooled from eight double-blind placebo-controlled studies conducted between 1999-2008 and included 110 healthy subjects who received 1-4 oral doses of psilocybin. Most subjects described the dose-dependent changes in mood, perception, thought and self-experience as pleasurable, enriching and non-threatening. Acute adverse drug reactions did not need psychopharmacological intervention.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
Are you affiliated with one of our partner associations?
Click here to gain complimentary access as part your association member benefits!
0 of 4 monthly FREE articles unlocked
