Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies
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OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(14):13 J Psychopharmacol. 2011 23-Feb;():. 10.1177/0269881110382466Study Summary
A meta-analysis was completed to analyze the acute, short- and long-term subjective effects of psilocybin in healthy humans. Raw data was pooled from eight double-blind placebo-controlled studies conducted between 1999-2008 and included 110 healthy subjects who received 1-4 oral doses of psilocybin. Most subjects described the dose-dependent changes in mood, perception, thought and self-experience as pleasurable, enriching and non-threatening. Acute adverse drug reactions did not need psychopharmacological intervention.
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