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Vitamin C reduces incidence of complex regional pain syndrome after distal radius fracture

Eur J Orthop Surg Traumatol. 2015 May;25(4):637-41.

Meta-analysis Hand & Wrist Upper Extremity Bone Radius Fracture Pain Syndrome Ascorbic Acid Placebo Prevention Vitamin - Hide

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6 wk Vitamin C Supplementation Improves Pain and Function vs. Placebo After Foot and Ankle Surgery

Foot Ankle Surg. 2019 Aug;25(4):542-545.

RCT Foot & Ankle Foot Trauma Lower Extremity Ankle Fracture Pain Placebo Post-Operative Vitamin - Hide

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No added benefit of vitamin C on functional outcomes or healing of distal radial fractures

J Bone Joint Surg Am. 2014 Sep 3;96(17):1451-9. doi: 10.2106/JBJS.M.00268.

RCT Trauma Bone Radius Fracture Placebo Vitamin - Hide

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500mg dose of Vitamin C effective in preventing complex regional pain syndrome

J Bone Joint Surg Am. 2007 Jul;89(7):1424-31

RCT Trauma Upper Extremity Wrist Fracture Pain Syndrome Placebo Preventing Vitamin - Hide

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Vitamin K2 is effective for management of osteoporosis in postmenopausal women

Osteoporos Int. 2015 Mar;26(3):1175-86.

Meta-analysis Metabolic Disorders Osteoporosis Postmenopausal Women Menatetrenone Oral Vitamin Preventing Prevention Supplements - Hide

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Effect of Supplemental Vitamin C on Function in Patients Suffering from Orthopaedic Disorders

Sci Rep. 2021 29-Apr;():. 10.1038/s41598-021-88864-7

Meta-analysis General Orthopaedics Foot Appendicular Lower Extremity Ankle Knee Fracture Arthroplasty Control Dietary supplement Vitamin C - Hide

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Vitamin D supplementation for bone mineral density increase in osteogenesis imperfecta

Bone. 2016 May;86:36-42

RCT Pediatric Orthopaedics Adolescent Osteogenesis High-Dose Vitamin - Hide

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WCO-IOF: Vitamin D supplementation appears to improve muscle function

Meta-analysis General Orthopaedics Control Muscle Strength Placebo Vitamin - Hide

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No beneficial effects of oral vitamin D3 on cartilage volume or knee pain in knee OA

JAMA. 2016 Mar 8;315(10):1005-13

RCT Osteoarthritis Lower Extremity Knee Bone Tibia Arthritis Cartilage Pain Oral Vitamin D3 Placebo - Hide

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Vitamin D does not improve radiological or clinical outcomes for patients with knee OA

Osteoarthritis Cartilage. 2016 Nov;24(11):1858-1866

RCT Osteoarthritis Lower Extremity Knee Joint Medial Compartment Arthritis Pain Oral Placebo Vitamin - Hide

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OARSI 2016: Efficacy of daily vitamin D3 vs placebo in patients with knee OA and low vitD

RCT Osteoarthritis Lower Extremity Knee Arthritis Placebo Vitamin D3 - Hide

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Adding Vitamin C in Bier Block Reduces Rate of Complex Regional Pain Syndrome After Wrist Fx Surgery

Eur J Orthop Surg Traumatol. 2021 01-May;():. 10.1007/s00590-020-02821-0

RCT Hand & Wrist Appendicular Upper Extremity Wrist Bone Radius Fracture Lidocaine Anesthetic Placebo Dietary supplement Vitamin C Bier Block Bier Block - Hide

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No significant effect of vitamin D3 supplementation on fracture union in hypovitaminosis patients

Bone Joint J. 2017 Nov;99-B(11):1520-1525

RCT Trauma Bone Femur Humerus Tibia Fracture Placebo Vitamin D3 - Hide

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Creep and early wear reduced with vitamin E-infused HXLPE cup versus UHMWPE cup in THA

J Bone Joint Surg Am. 2018 Jan 17;100(2):107-114

RCT Arthroplasty Osteoarthritis Lower Extremity Hip Arthritis Mathys Stryker HXLPE Infused Highly-Crosslinked Polyethylene Cup Monoblock UHMWPE Ultra-High-Molecular-Weight Polyethylene Vitamin - Hide

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EFORT: Vit-E dosed HXL polyethylene liner reduces wear vs. control UHMWPE liner

RCT Arthroplasty Lower Extremity Hip Control High-Molecular-Weight Non-Cemented Polyethylene Liner Vitamin - Hide

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Lower 5-year wear with vitamin-E infused HXLPE liner versus standard crosslinked liner in THA

Bone Joint J. 2018 Dec;100-B(12):1592-1599. doi: 10.1302/0301-620X.100B12.BJJ-2018-0371.R1

RCT Arthroplasty Osteoarthritis Lower Extremity Hip Arthritis Biomet CeramTec Zimmer Zimmer-Biomet Highly Crosslinked Polyethylene Infused Polyethylene Liner Vitamin - Hide

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Prevalence of vitamin D inadequacy in athletes is prominent

Sports Med. 2015 Mar;45(3):365-78

Meta-analysis Sports Medicine Athletes Control Observational Vitamin - Hide

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Osteoporotic fracture rate not significantly improved by vitamin B-12 or folic acid intake

Am J Clin Nutr. 2014 Dec;100(6):1578-86.

RCT Metabolic Disorders Elderly Osteoporosis Fracture Vitamin B-12 Acid Placebo - Hide

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AAOS: Role of Vitamin D in Osteoarthritis Knee

RCT Osteoarthritis Lower Extremity Knee Arthritis Control Placebo Vitamin - Hide

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AAOS2017: Vitamin D supplementation in hip fracture patients

RCT Trauma Elderly Lower Extremity Hip Bone Femur Neck Fracture Vitamin - Hide

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Vitamin C reduces incidence of complex regional pain syndrome after distal radius fracture

6 wk Vitamin C Supplementation Improves Pain and Function vs. Placebo After Foot and Ankle Surgery

No added benefit of vitamin C on functional outcomes or healing of distal radial fractures

500mg dose of Vitamin C effective in preventing complex regional pain syndrome

Vitamin K2 is effective for management of osteoporosis in postmenopausal women

Effect of Supplemental Vitamin C on Function in Patients Suffering from Orthopaedic Disorders

Vitamin D supplementation for bone mineral density increase in osteogenesis imperfecta

WCO-IOF: Vitamin D supplementation appears to improve muscle function

No beneficial effects of oral vitamin D3 on cartilage volume or knee pain in knee OA

Vitamin D does not improve radiological or clinical outcomes for patients with knee OA

OARSI 2016: Efficacy of daily vitamin D3 vs placebo in patients with knee OA and low vitD

Adding Vitamin C in Bier Block Reduces Rate of Complex Regional Pain Syndrome After Wrist Fx Surgery

No significant effect of vitamin D3 supplementation on fracture union in hypovitaminosis patients

Creep and early wear reduced with vitamin E-infused HXLPE cup versus UHMWPE cup in THA

EFORT: Vit-E dosed HXL polyethylene liner reduces wear vs. control UHMWPE liner

Lower 5-year wear with vitamin-E infused HXLPE liner versus standard crosslinked liner in THA

Prevalence of vitamin D inadequacy in athletes is prominent

Osteoporotic fracture rate not significantly improved by vitamin B-12 or folic acid intake

AAOS: Role of Vitamin D in Osteoarthritis Knee

AAOS2017: Vitamin D supplementation in hip fracture patients

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Emerging Treatments

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