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Autologous blood product injection no more effective than placebo saline for Achilles tendinopathy

Arthroscopy. 2018 Jun;34(6):1966-1975

Meta-analysis Foot & Ankle Athletes Lower Extremity Muscle Achilles Tendinopathy Autologous Blood Placebo Injection Placebo Saline Platelet-Rich Plasma - Hide

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OARSI 2016: Efficacy of intramuscular corticosteroid injection vs. placebo for hip OA

RCT Osteoarthritis Lower Extremity Hip Muscle Gluteus Arthritis Pain Stiffness Corticosteroid Injection IM Intramuscular Injection Placebo Injection - Hide

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Corticosteroid injection not effective in treatment of lateral epicondylalgia

JAMA. 2013 Feb 6;309(5):461-9. doi: 10.1001/jama.2013.129

RCT Shoulder & Elbow Upper Extremity Epicondyle Corticosteroid Injection Physiotherapy Single Injection - Hide

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Dehydrated human amnion/chorion membrane (dHACM) injection vs. placebo for plantar fasciitis

Foot Ankle Int. 2018 Oct;39(10):1151-1161. doi: 10.1177/1071100718788549

RCT Foot & Ankle Lower Extremity Muscle Plantar Fascia Plantar Fasciitis MiMedx Injection Fascia Placebo Sodium Chloride - Hide

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Hylan injection no different than placebo injection for pain improvement in hip osteoarthritis

Osteoarthritis Cartilage. 2019 Jan;27(1):59-70. doi: 10.1016/j.joca.2018.08.018.

RCT Osteoarthritis Lower Extremity Hip Arthritis Pain Sanofi Hylan Placebo Saline Single Intraarticular Injection - Hide

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Extended-release triamcinolone acetonide (FX006) versus placebo in knee osteoarthritis treatment

J Bone Joint Surg Am. 2018 Apr 18;100(8):666-677

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Flexion Therapeutics Extended-Release Placebo Single Injection Triamcinolone Acetonide - Hide

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No difference in 1-wk pain and function improvement between steroid vs placebo injection for knee OA

Ann Rheum Dis. 2014 Aug;73(8):1590-1. doi: 10.1136/annrheumdis-2014-205206

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Methylprednisolone Intraarticular Injection Placebo Injection Ultrasound - Hide

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Better longer-term results with PRP versus CS and placebo injection for plantar fasciitis

J Foot Ankle Surg. 2019 Jan;58(1):42-46. doi: 10.1053/j.jfas.2018.07.006

RCT Foot & Ankle Lower Extremity Muscle Plantar Fascia Plantar Fasciitis Methylprednisolone Lidocaine Placebo Platelet Rich Plasma PRP Single Injection - Hide

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Subacromial Corticosteroid Injection effective for patients with Hemiplegic Shoulder Pain

Arch Phys Med Rehabil. 2012 Jun;93(6):949-56. doi: 10.1016/j.apmr.2012.02.002. Epub 2012 Apr 5

RCT Shoulder & Elbow Upper Extremity Shoulder Bone Subacromial Muscle Rotator Cuff Pain Lidocaine Placebo Subacromial Corticosteroid Injection - Hide

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Hyaluronic acid injection similar in symptom & structure of knee OA vs diacerein & placebo

Ann Rheum Dis. 2004 Dec;63(12):1611-7

RCT Osteoarthritis Lower Extremity Knee Arthritis Roussel Diacerein Injections Hyaluronic Acid Oral Placebo Saline - Hide

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Significant 3-week pain reduction with methylprednisolone vs saline injection for knee OA

Ann Rheum Dis. 1996 Nov;55(11):829-32

RCT Osteoarthritis Lower Extremity Knee Muscle Quadricep Arthritis Pain Corticosteroid Injection Methylprednisolone Acetate Reduction Saline Injection - Hide

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No significant difference in effect on cartilage volume between HA vs placebo injection

Clin Exp Pharmacol 2012, 2:2

RCT Osteoarthritis Women Lower Extremity Knee Arthritis Cartilage Injections HA MRI Placebo Sodium Hyaluronate - Hide

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Hypertonic Dextrose Injection Improves Clinical Outcomes in Patients with Supraspinatus Tendinopathy

Eur J Phys Rehabil Med. 2019 Aug;55(4):480-487.

RCT Shoulder & Elbow Upper Extremity Shoulder Muscle Supraspinatus Supraspinatus Tendon Pain Tendinopathy Injection Dextrose Placebo Saline - Hide

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Not all injection therapies effective in improving pain in patients with tennis elbow

Am J Sports Med. 2013 Jun;41(6):1435-46. doi: 10.1177/0363546512458237. Epub 2012 Sep 12

Meta-analysis Shoulder & Elbow Upper Extremity Elbow Epicondyle Pain Epicondylitis Glucocorticoid Autologous Blood Botulinum Toxin Hyaluronic Acid Information Placebo Platelet-Rich Plasma Prolotherapy PRP Toxin Injections - Hide

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Botulinum Toxin A injection is an effective treatment for radial epicondylitis

J Bone Joint Surg Am. 2007 Feb;89(2):255-60.

RCT Shoulder & Elbow Upper Extremity Elbow Forearm Bone Radius Epicondyle Epicondylitis Ipsen Injection Of Botulinum Toxin Placebo - Hide

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Comparing hydrocortisone acetate/t-butylacetate vs placebo injection for knee OA

Ann Rheum Dis. 1960 Sep;19:257-61

RCT Osteoarthritis Lower Extremity Knee Arthritis Acetate Injections Hydrocortisone Placebo Injection - Hide

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Combined hyaluronic acid and corticosteroid injection reduces pain compared to placebo

Cartilage. 2017 May. doi: 10.1177/1947603517703732.

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Anika Monovisc Injection Corticosteroid Hyaluronic Acid Placebo Sodium Hyaluronate Triamcinolone Hexacetonide - Hide

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BoNT-A injection within ECRB demonstrates efficacy versus placebo for lateral epicondylitis

J Bone Joint Surg Am. 2018 May 16;100(10):818-826

RCT Shoulder & Elbow Upper Extremity Epicondyle Epicondylitis Tendinopathy Ipsen Injection Botulinum Toxin Extensor Guidance Placebo Saline Stimulation - Hide

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Single intra-articular injection of hylarunon not effective for treatment of first MTPJ OA

Ann Rheum Dis. 2011 Oct;70(10):1838-41. doi: 10.1136/ard.2011.153049. Epub 2011 Jul 25

RCT Hand & Wrist Osteoarthritis Upper Extremity Arthritis Pain Osteophytes Genzyme Hylan Hyaluronan Paracetamol Injection Placebo Saline - Hide

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AAOS 2016: High-dose hyaluronate reduces pain versus placebo for plantar fasciitis

RCT Foot & Ankle Lower Extremity Muscle Plantar Fascia Pain Plantar Fasciitis Injections High-Dose Hyaluronate Low-Dose Placebo - Hide

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Autologous blood product injection no more effective than placebo saline for Achilles tendinopathy

OARSI 2016: Efficacy of intramuscular corticosteroid injection vs. placebo for hip OA

Corticosteroid injection not effective in treatment of lateral epicondylalgia

Dehydrated human amnion/chorion membrane (dHACM) injection vs. placebo for plantar fasciitis

Hylan injection no different than placebo injection for pain improvement in hip osteoarthritis

Extended-release triamcinolone acetonide (FX006) versus placebo in knee osteoarthritis treatment

No difference in 1-wk pain and function improvement between steroid vs placebo injection for knee OA

Better longer-term results with PRP versus CS and placebo injection for plantar fasciitis

Subacromial Corticosteroid Injection effective for patients with Hemiplegic Shoulder Pain

Hyaluronic acid injection similar in symptom & structure of knee OA vs diacerein & placebo

Significant 3-week pain reduction with methylprednisolone vs saline injection for knee OA

No significant difference in effect on cartilage volume between HA vs placebo injection

Hypertonic Dextrose Injection Improves Clinical Outcomes in Patients with Supraspinatus Tendinopathy

Not all injection therapies effective in improving pain in patients with tennis elbow

Botulinum Toxin A injection is an effective treatment for radial epicondylitis

Comparing hydrocortisone acetate/t-butylacetate vs placebo injection for knee OA

Combined hyaluronic acid and corticosteroid injection reduces pain compared to placebo

BoNT-A injection within ECRB demonstrates efficacy versus placebo for lateral epicondylitis

Single intra-articular injection of hylarunon not effective for treatment of first MTPJ OA

AAOS 2016: High-dose hyaluronate reduces pain versus placebo for plantar fasciitis

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Emerging Treatments

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