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Musculoskeletal Evidence
Osteoarthritis
The effect of a topical curcumin formulation (VAS-101) on knee pain in adults with knee osteoarthritis: a randomised, double-blind, placebo-controlled study.
Front Pain Res (Lausanne). 2026 01-Apr;():. 10.3389/fpain.2026.1789088
The effect of a topical curcumin formulation (VAS-101) on knee pain in adults with knee osteoarthritis: a randomised, double-blind, placebo-controlled study.
Front Pain Res (Lausanne). 2026 01-Apr;():. 10.3389/fpain.2026.1789088
Shoulder & Elbow
Plasma-Rich Plasma Does Not Improve Pain or Function in Patients with Lateral Epicondylitis Compared to Placebo
Plasma-Rich Plasma Does Not Improve Pain or Function in Patients with Lateral Epicondylitis Compared to Placebo
Spine
Immediate effects of myofascial technique for the treatment of chronic nonspecific neck pain in adults: a randomized placebo-controlled trial.
Physiother Theory Pract. 2026 01-Mar;():. 10.1080/09593985.2025.2579592
Immediate effects of myofascial technique for the treatment of chronic nonspecific neck pain in adults: a randomized placebo-controlled trial.
Physiother Theory Pract. 2026 01-Mar;():. 10.1080/09593985.2025.2579592
Hand & Wrist
Wrist Splinting versus a Placebo Soft Bandage for Carpal Tunnel Syndrome.
NEJM Evid. 2026 01-Mar;():. 10.1056/EVIDoa2500261
Wrist Splinting versus a Placebo Soft Bandage for Carpal Tunnel Syndrome.
NEJM Evid. 2026 01-Mar;():. 10.1056/EVIDoa2500261
Spine
Erector Spinae Plane Block in Multimodal Analgesia After Lumbar Spinal Fusion Surgery: A Blinded Randomized Placebo-Controlled Trial.
Anesth Analg. 2026 01-Mar;():. 10.1213/ANE.0000000000007611
Erector Spinae Plane Block in Multimodal Analgesia After Lumbar Spinal Fusion Surgery: A Blinded Randomized Placebo-Controlled Trial.
Anesth Analg. 2026 01-Mar;():. 10.1213/ANE.0000000000007611
Osteoarthritis
Effectiveness of genicular nerve block on pain and disability in chronic knee osteoarthritis: a randomized double blinded placebo controlled trial.
Clin Rheumatol. 2026 01-Feb;():. 10.1007/s10067-025-07818-w
Effectiveness of genicular nerve block on pain and disability in chronic knee osteoarthritis: a randomized double blinded placebo controlled trial.
Clin Rheumatol. 2026 01-Feb;():. 10.1007/s10067-025-07818-w
Osteoarthritis
Complications of Platelet-Rich Plasma Injection for Knee Osteoarthritis Are Similar to Those of Corticosteroids and Hyaluronic Acid but Are Significantly Greater Than Those of Placebo Injections: A Meta-analysis of Randomized Controlled Trials.
Arthroscopy. 2025 01-Nov;():. 10.1016/j.arthro.2025.05.018
This study has been identified as potentially high impact.
OE's AI-driven High Impact metric estimates the influence a paper is likely to have by integrating signals from both the journal in which it is published and the scientific content of the article itself.
Developed using state-of-the-art natural language processing, the OE High Impact model more accurately predicts a study's future citation performance than journal impact factor alone.
This enables earlier recognition of clinically meaningful research and helps readers focus on articles most likely to shape future practice.
Complications of Platelet-Rich Plasma Injection for Knee Osteoarthritis Are Similar to Those of Corticosteroids and Hyaluronic Acid but Are Significantly Greater Than Those of Placebo Injections: A Meta-analysis of Randomized Controlled Trials.
Arthroscopy. 2025 01-Nov;():. 10.1016/j.arthro.2025.05.018
Osteoarthritis
Randomized, Double-Blind, Placebo-Controlled Trial of ID-CBT5101, a Tyndallized Clostridium butyricum Postbiotic, in Adults with Mild-to-Moderate Knee Osteoarthritis.
J Microbiol Biotechnol. 2026 01-Jan;():. 10.4014/jmb.2512.12024
Randomized, Double-Blind, Placebo-Controlled Trial of ID-CBT5101, a Tyndallized Clostridium butyricum Postbiotic, in Adults with Mild-to-Moderate Knee Osteoarthritis.
J Microbiol Biotechnol. 2026 01-Jan;():. 10.4014/jmb.2512.12024
Shoulder & Elbow
Transauricular Vagus Nerve Stimulation for Postoperative Analgesia following Arthroscopic Shoulder Surgery: A Double-Blind, Randomized, Placebo-Controlled Trial.
Pain Ther. 2025 01-Dec;():. 10.1007/s40122-025-00785-9
Transauricular Vagus Nerve Stimulation for Postoperative Analgesia following Arthroscopic Shoulder Surgery: A Double-Blind, Randomized, Placebo-Controlled Trial.
Pain Ther. 2025 01-Dec;():. 10.1007/s40122-025-00785-9
Osteoarthritis
Efficacy of intra-articular platelet-rich plasma compared with placebo in knee osteoarthritis: A systematic review and meta-analysis.
Joint Bone Spine. 2025 01-Dec;():. 10.1016/j.jbspin.2025.105947
This study has been identified as potentially high impact.
OE's AI-driven High Impact metric estimates the influence a paper is likely to have by integrating signals from both the journal in which it is published and the scientific content of the article itself.
Developed using state-of-the-art natural language processing, the OE High Impact model more accurately predicts a study's future citation performance than journal impact factor alone.
This enables earlier recognition of clinically meaningful research and helps readers focus on articles most likely to shape future practice.
Efficacy of intra-articular platelet-rich plasma compared with placebo in knee osteoarthritis: A systematic review and meta-analysis.
Joint Bone Spine. 2025 01-Dec;():. 10.1016/j.jbspin.2025.105947
Osteoarthritis
Effects of orally administered cetylated fatty acids on symptoms and functional capacity in patients with knee osteoarthritis: results of a randomized, double-blind, placebo-controlled study.
Eur J Clin Nutr. 2025 01-Nov;():. 10.1038/s41430-025-01656-4
Effects of orally administered cetylated fatty acids on symptoms and functional capacity in patients with knee osteoarthritis: results of a randomized, double-blind, placebo-controlled study.
Eur J Clin Nutr. 2025 01-Nov;():. 10.1038/s41430-025-01656-4
Arthroplasty
Oral Corticosteroids Reduce Pain After Total Knee Arthroplasty: A Higher Dose of Dexamethasone Effectively Controlled Pain During Motion: A Dose-Response Randomized Placebo-Controlled Trial.
J Bone Joint Surg Am. 2026 01-Jan;():. 10.2106/JBJS.25.00642
This study has been identified as potentially high impact.
OE's AI-driven High Impact metric estimates the influence a paper is likely to have by integrating signals from both the journal in which it is published and the scientific content of the article itself.
Developed using state-of-the-art natural language processing, the OE High Impact model more accurately predicts a study's future citation performance than journal impact factor alone.
This enables earlier recognition of clinically meaningful research and helps readers focus on articles most likely to shape future practice.
Oral Corticosteroids Reduce Pain After Total Knee Arthroplasty: A Higher Dose of Dexamethasone Effectively Controlled Pain During Motion: A Dose-Response Randomized Placebo-Controlled Trial.
J Bone Joint Surg Am. 2026 01-Jan;():. 10.2106/JBJS.25.00642
Arthroplasty
Does Melatonin Improve Sleep Following Primary Total Hip Arthroplasty: A Randomized, Double-Blind, Placebo-Controlled Trial
Does Melatonin Improve Sleep Following Primary Total Hip Arthroplasty: A Randomized, Double-Blind, Placebo-Controlled Trial
Osteoarthritis
Effect of platelet-rich plasma versus placebo or corticosteroid for knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials.
J Clin Orthop Trauma. 2025 01-Mar;():. 10.1016/j.jcot.2024.102870
Effect of platelet-rich plasma versus placebo or corticosteroid for knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials.
J Clin Orthop Trauma. 2025 01-Mar;():. 10.1016/j.jcot.2024.102870
General Orthopaedics
Effect of ultrasound-guided fascia iliaca compartment block on pain management in hip fracture patients: A double-blind placebo-controlled randomized clinical trial.
Medicine (Baltimore). 2025 01-Oct;():. 10.1097/MD.0000000000044622
Effect of ultrasound-guided fascia iliaca compartment block on pain management in hip fracture patients: A double-blind placebo-controlled randomized clinical trial.
Medicine (Baltimore). 2025 01-Oct;():. 10.1097/MD.0000000000044622
General Orthopaedics
Prophylactic administration of parecoxib sodium for postoperative delirium in hip surgery of the elderly: a prospective, randomized, placebo-controlled trial.
Rev Assoc Med Bras (1992). 2025 01-Sep;():. 10.1590/1806-9282.20250548
Prophylactic administration of parecoxib sodium for postoperative delirium in hip surgery of the elderly: a prospective, randomized, placebo-controlled trial.
Rev Assoc Med Bras (1992). 2025 01-Sep;():. 10.1590/1806-9282.20250548
Osteoarthritis
Probiotics improve functional performance in patients with osteoarthritis: a randomized placebo-controlled clinical trial.
Eur J Nutr. 2025 01-Oct;():. 10.1007/s00394-025-03805-8
Probiotics improve functional performance in patients with osteoarthritis: a randomized placebo-controlled clinical trial.
Eur J Nutr. 2025 01-Oct;():. 10.1007/s00394-025-03805-8
Physical Therapy & Rehab
Short-term effects of classical massage added to a conventional physiotherapy on non-specific chronic low back Pain: A randomized, placebo-controlled study.
J Bodyw Mov Ther. 2025 01-Oct;():. 10.1016/j.jbmt.2025.05.036
Short-term effects of classical massage added to a conventional physiotherapy on non-specific chronic low back Pain: A randomized, placebo-controlled study.
J Bodyw Mov Ther. 2025 01-Oct;():. 10.1016/j.jbmt.2025.05.036
Shoulder & Elbow
Metformin Reduces the Incidence of Shoulder Stiffness After Arthroscopic Rotator Cuff Repair: A Randomized, Double-Blinded, Placebo-Controlled Trial.
Am J Sports Med. 2025 01-Oct;():. 10.1177/03635465251380296
This study has been identified as potentially high impact.
OE's AI-driven High Impact metric estimates the influence a paper is likely to have by integrating signals from both the journal in which it is published and the scientific content of the article itself.
Developed using state-of-the-art natural language processing, the OE High Impact model more accurately predicts a study's future citation performance than journal impact factor alone.
This enables earlier recognition of clinically meaningful research and helps readers focus on articles most likely to shape future practice.
Metformin Reduces the Incidence of Shoulder Stiffness After Arthroscopic Rotator Cuff Repair: A Randomized, Double-Blinded, Placebo-Controlled Trial.
Am J Sports Med. 2025 01-Oct;():. 10.1177/03635465251380296
Arthroplasty
Analgesic efficacy of ultrasound-guided genicular nerve block in combination with adductor canal block in total knee arthroplasty: A randomised, double-blind, placebo-controlled trial.
Indian J Anaesth. 2025 01-Sep;():. 10.4103/ija.ija_486_25
Analgesic efficacy of ultrasound-guided genicular nerve block in combination with adductor canal block in total knee arthroplasty: A randomised, double-blind, placebo-controlled trial.
Indian J Anaesth. 2025 01-Sep;():. 10.4103/ija.ija_486_25
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