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The efficacy & safety of various doses of fulranumab vs placebo for chronic LBP

Clin Ther. 2016 Jun;38(6):1435-50

RCT Spine Low Back Axial Skeleton Back Pain Amgen Injection Fulranumab Placebo - Hide

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Hyaluronic acid injection similar in symptom & structure of knee OA vs diacerein & placebo

Ann Rheum Dis. 2004 Dec;63(12):1611-7

RCT Osteoarthritis Lower Extremity Knee Arthritis Roussel Diacerein Injections Hyaluronic Acid Oral Placebo Saline - Hide

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OARSI 2016: Glucosamine and chondroitin not more effective than placebo for knee OA

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Chondroitin Sulfate Glucosamine Sulfate Oral Placebo - Hide

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Single-dose intra-articular bupivacaine significantly reduces pain after knee arthroscopy

Knee Surg Sports Traumatol Arthrosc. 2014 Jul;22(7):1517-28

Meta-analysis General Orthopaedics Lower Extremity Knee Pain Bupivacaine Analgesia Analgesic Arthroscopic Surgery Arthroscopy IA Placebo Reduction Single-Dose - Hide

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Glucosamine + chondroitin reduced joint space narrowing at 2 years vs. placebo in knee OA

Ann Rheum Dis. 2015 May;74(5):851-8.

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Aventis Sanofi Chondroitin Glucosamine Placebo - Hide

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Capsaicin provide comparable or better pain and functional improvement than placebo

Clin Drug Investig. 2011 Dec 1;31(12):877-82. doi: 10.2165/11593860-000000000-00000

RCT Arthroplasty Osteoarthritis Wound Lower Extremity Knee Arthritis Pain Anesiva Capsaicin Placebo - Hide

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Nabiximols improves multiple sclerosis spasticity compared to placebo over 12 weeks

Eur J Neurol. 2011 Sep;18(9):1122-31. doi: 10.1111/j.1468-1331.2010.03328.x

RCT Cannabis Placebo Pump Spray - Hide

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AAOS 2016: High-dose hyaluronate reduces pain versus placebo for plantar fasciitis

RCT Foot & Ankle Lower Extremity Muscle Plantar Fascia Pain Plantar Fasciitis Injections High-Dose Hyaluronate Low-Dose Placebo - Hide

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Titrated THC:CBD Improves Pain and Spasticity Compared to Placebo Over 12 Weeks for Resistant MS

Int J Neurosci. 2018 Sep 13:1-10.

RCT Cannabis Pain Placebo Spray Cannabidiol - Hide

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Dronabinol increases pain threshold compared to placebo for functional chest pain over 4 weeks

Dis Esophagus. 2017 Feb 1;30(2):1-8. doi: 10.1111/dote.12455

RCT Cannabis Pain Placebo - Hide

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AAOS: Hyaluronic acid and placebo produce similar pain and functional outcomes for knee OA

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain HA Hyaluronic Acid Placebo Injections - Hide

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WCO-IOF: Dynamic electroneurostimulation vs placebo for osteoporotic spine fractures

RCT Spine Osteoporosis Postmenopausal Women Axial Skeleton Back Joint Vertebral Fracture Pain Dynamic Electroneurostimulation Placebo - Hide

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Chrondroitin sulfate improves pain and function compared to placebo in the management of knee OA

Ann Rheum Dis. 2017 May 22. pii: annrheumdis-2016-210860. doi: 10.1136/annrheumdis-2016-210860. [Epub ahead of print]

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Innovative Neurotronics Institut Biochimique Pfizer Celecoxib Chondroitin Sulfate Placebo - Hide

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Extended-release triamcinolone acetonide (FX006) versus placebo in knee osteoarthritis treatment

J Bone Joint Surg Am. 2018 Apr 18;100(8):666-677

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Flexion Therapeutics Extended-Release Placebo Single Injection Triamcinolone Acetonide - Hide

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Celecoxib and naproxen beneficial in Asian patients with knee OA compared to a placebo

Int J Rheum Dis. 2016 Mar;19(3):262-70

RCT Osteoarthritis Lower Extremity Knee Arthritis Inflammation Pfizer Celecoxib Naproxen Nonsteroidal Placebo - Hide

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Delta 9-THC has better analgesic efficacy versus placebo for neuropathic pain over 6 hours

J Pain. 2008 Jun;9(6):506-21. doi: 10.1016/j.jpain.2007.12.010

RCT Cannabis Nerve Axial Skeleton Spine Pain Neuropathy Syndrome Placebo - Hide

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Rofecoxib and celecoxib demonstrate similar, significant 6-week efficacy vs placebo in OA treatment

Curr Med Res Opin. 2006 Jan;22(1):199-210

RCT Osteoarthritis Lower Extremity Knee Arthritis Merck Celecoxib Rofecoxib Placebo - Hide

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Vertebroplasty for osteoporotic fractures yield no benefit over placebo at 2-years

J Bone Miner Res. 2014 Jun;29(6):1346-55.

RCT Spine Osteoporosis Axial Skeleton Back Joint Vertebral Fracture Pain Placebo Vertebroplasty - Hide

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WCO-IOF 2016: Lasofoxifene, raloxifene, and placebo for BMD in postmenopausal women

RCT Metabolic Disorders Postmenopausal Women Axial Skeleton Spine Spine Lumbar Raloxifene Lasofoxifene Placebo - Hide

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Oral tetrahydrocannabinol (THC) does not reduce chronic abdominal pain compared to placebo

Clin Gastroenterol Hepatol. 2017 Jul;15(7):1079-1086.e4. doi: 10.1016/j.cgh.2016.09.147

RCT Cannabis Muscle Abdominal Pain Placebo - Hide

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The efficacy & safety of various doses of fulranumab vs placebo for chronic LBP

Hyaluronic acid injection similar in symptom & structure of knee OA vs diacerein & placebo

OARSI 2016: Glucosamine and chondroitin not more effective than placebo for knee OA

Single-dose intra-articular bupivacaine significantly reduces pain after knee arthroscopy

Glucosamine + chondroitin reduced joint space narrowing at 2 years vs. placebo in knee OA

Capsaicin provide comparable or better pain and functional improvement than placebo

Nabiximols improves multiple sclerosis spasticity compared to placebo over 12 weeks

AAOS 2016: High-dose hyaluronate reduces pain versus placebo for plantar fasciitis

Titrated THC:CBD Improves Pain and Spasticity Compared to Placebo Over 12 Weeks for Resistant MS

Dronabinol increases pain threshold compared to placebo for functional chest pain over 4 weeks

AAOS: Hyaluronic acid and placebo produce similar pain and functional outcomes for knee OA

WCO-IOF: Dynamic electroneurostimulation vs placebo for osteoporotic spine fractures

Chrondroitin sulfate improves pain and function compared to placebo in the management of knee OA

Extended-release triamcinolone acetonide (FX006) versus placebo in knee osteoarthritis treatment

Celecoxib and naproxen beneficial in Asian patients with knee OA compared to a placebo

Delta 9-THC has better analgesic efficacy versus placebo for neuropathic pain over 6 hours

Rofecoxib and celecoxib demonstrate similar, significant 6-week efficacy vs placebo in OA treatment

Vertebroplasty for osteoporotic fractures yield no benefit over placebo at 2-years

WCO-IOF 2016: Lasofoxifene, raloxifene, and placebo for BMD in postmenopausal women

Oral tetrahydrocannabinol (THC) does not reduce chronic abdominal pain compared to placebo

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Emerging Treatments

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Evidence Series

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