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Patellofemoral pain: High-dose high-repetition vs low dose, low repetition exercise

Physiotherapy. 2013 Jun;99(2):126-31. doi: 10.1016/j.physio.2012.05.009. Epub 2012 Jul 24

RCT Physical Therapy & Rehab Joint Patellofemoral Pain Syndrome High-Dose Low-Dose Medical Exercise Therapy - Hide

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High-dose TXA more effective than low-dose TXA and placebo for reducing blood loss in PLIF

Eur Spine J. 2017 Nov;26(11):2851-2857

RCT Spine Stenosis Axial Skeleton Lumbar Spinal Stenosis Tranexamic Acid Bolus High-Dose TXA Interbody Fusion Low-Dose Placebo Saline - Hide

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OTA 2014: High-dose vitamin D vs. placebo in deficient patients with long bone fracture

RCT Trauma Bone Femur Humerus Tibia Fracture High-Dose Oral Placebo Vitamin - Hide

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ISAKOS2017: Similar 12-week outcome between high- and low-dose steroid for shoulder stiffness

RCT Shoulder & Elbow Upper Extremity Shoulder Stiffness Low-Dose Steroid Triamcinolone Acetonide Ultrasound-Guided Injection - Hide

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Similar ROM and clinical scores between high & low-dose corticosteroid for shoulder stiffness

J Shoulder Elbow Surg. 2017 Feb;26(2):209-215

RCT Shoulder & Elbow Upper Extremity Shoulder Stiffness Lidocaine High-Dose Low-Dose Triamcinolone Acetonide Ultrasound-Guided Intraarticular Injection - Hide

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Osteosarcoma: methotrexate & doxorubicin versus methotrexate, etoposide & ifosfamide

Eur J Cancer. 2007 Mar;43(4):752-61. Epub 2007 Jan 30

RCT Tumour Osteosarcoma Doxorubicin Etoposide-Ifosfamide High-Dose Methotrexate Infusion Preoperative Chemotherapy - Hide

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No difference between high- and low-dose corticosteroid injection for shoulder pain

Arch Phys Med Rehabil. 2011 Dec;92(12):1951-60. doi: 10.1016/j.apmr.2011.06.033. Epub 2011 Oct 25

RCT Shoulder & Elbow Upper Extremity Shoulder Bone Subacromial Pain Lidocaine Corticosteroid Low-Dose Placebo Subacromial Injection Triamcinolone Acetonide - Hide

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High- and low-dose BM-MSC injection versus control for treatment of knee osteoarthritis

J Transl Med. 2016 Aug 26;14(1):246. doi: 10.1186/s12967-016-0998-2

RCT Osteoarthritis Lower Extremity Knee Arthritis Autologous Bone Marrow Injection Control High-Dose Hyaluronic Acid Low-Dose - Hide

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High dose vitamin D increases risk of falls and fractures in older women

JAMA. 2010 May 12;303(18):1815-22.

RCT General Orthopaedics Community-Dwelling Elderly Falls Women Lower Extremity Hip Fracture Cholecalciferol Placebo Vitamin - Hide

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AAOS 2016: High-dose hyaluronate reduces pain versus placebo for plantar fasciitis

RCT Foot & Ankle Lower Extremity Muscle Plantar Fascia Pain Plantar Fasciitis Injections High-Dose Hyaluronate Low-Dose Placebo - Hide

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Low-dose intraoperative CT imaging does not reduce pedicle screw accuracy in spinal fusion

Eur Spine J. 2017 Nov;26(11):2818-2827

RCT Spine Axial Skeleton Lumbar Thoracic Bone Pedicle Siemens Fusion High-Dose Imaging Intraoperative CT Low-Dose Pedicle Screw Radiation - Hide

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Pain reduction greater with 5 injections of high-dose HA vs control for plantar fasciopathy

Knee Surg Sports Traumatol Arthrosc. 2018 Mar;26(3):903-911

RCT Foot & Ankle Lower Extremity Muscle Plantar Fascia Pain Chugai Pharmaceutical Injections Control High-Dose HA Hyaluronic Acid Low-Dose Reduction - Hide

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Low- and high-dose TXA effective in reducing blood loss and transfusion needs in TKA

BMC Musculoskelet Disord. 2013 Dec 5;14:340. doi: 10.1186/1471-2474-14-340

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Zimmer NexGen Tranexamic Acid Drain Fascia Closure High-Dose Low-Dose TXA - Hide

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TKA: preoperative methylprednisolone effective for pain and recovery

Br J Anaesth. 2011 Feb;106(2)

RCT Arthroplasty Lower Extremity Knee Pain Methylprednisolone Sufentanil Oxycodone Ondansetron High-Dose Placebo Preoperatively TKA - Hide

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Vitamin D supplementation for bone mineral density increase in osteogenesis imperfecta

Bone. 2016 May;86:36-42

RCT Pediatric Orthopaedics Adolescent Osteogenesis High-Dose Vitamin - Hide

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High Loading Dose & Daily High and Low Dose Vitamin D3 Supplementation on Acute Fracture Healing

JBMR Plus. 2023 01-Jan;():. 10.1002/jbm4.10705

RCT Trauma Appendicular Lower Extremity Lower Leg Bone Femur Tibia Fracture Placebo Vitamin D3 Dietary supplement Bio-Tech Pharmacal Bio-Tech Pharmacal Bio-Tech Pharmacal Bio-Tech Pharmacal - Hide

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Pulsed shortwave treatment in women with knee osteoarthritis

Physical Therapy; 2011; 91(7):1009-1017

RCT Osteoarthritis Elderly Women Lower Extremity Knee Arthritis Placebo Pulsed - Hide

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High-dose vitD has no significant effect, positive or negative, compared to low-dose after TKA

RMD Open. 2018 Jul 9;4(2):e000678. doi: 10.1136/rmdopen-2018-000678

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Vitamin D3 - Hide

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AAOS 2016: Single-dose vitamin D does not reduce nonunion rate in acute long bone fracture

RCT Trauma Bone Femur Humerus Tibia Fracture Nonunion Placebo Vitamin - Hide

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Adhesive capsulitis: Pain & disability improved similarly with 20mg & 40mg corticosteroid

Am J Sports Med. 2013 May;41(5):1133-9. doi: 10.1177/0363546513480475. Epub 2013 Mar 18

RCT Shoulder & Elbow Capsulitis Upper Extremity Pain Lidocaine Triamcinolone Adhesive Injection Corticosteroid Guided High-Dose Placebo - Hide

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Patellofemoral pain: High-dose high-repetition vs low dose, low repetition exercise

High-dose TXA more effective than low-dose TXA and placebo for reducing blood loss in PLIF

OTA 2014: High-dose vitamin D vs. placebo in deficient patients with long bone fracture

ISAKOS2017: Similar 12-week outcome between high- and low-dose steroid for shoulder stiffness

Similar ROM and clinical scores between high & low-dose corticosteroid for shoulder stiffness

Osteosarcoma: methotrexate & doxorubicin versus methotrexate, etoposide & ifosfamide

No difference between high- and low-dose corticosteroid injection for shoulder pain

High- and low-dose BM-MSC injection versus control for treatment of knee osteoarthritis

High dose vitamin D increases risk of falls and fractures in older women

AAOS 2016: High-dose hyaluronate reduces pain versus placebo for plantar fasciitis

Low-dose intraoperative CT imaging does not reduce pedicle screw accuracy in spinal fusion

Pain reduction greater with 5 injections of high-dose HA vs control for plantar fasciopathy

Low- and high-dose TXA effective in reducing blood loss and transfusion needs in TKA

TKA: preoperative methylprednisolone effective for pain and recovery

Vitamin D supplementation for bone mineral density increase in osteogenesis imperfecta

High Loading Dose & Daily High and Low Dose Vitamin D3 Supplementation on Acute Fracture Healing

Pulsed shortwave treatment in women with knee osteoarthritis

High-dose vitD has no significant effect, positive or negative, compared to low-dose after TKA

AAOS 2016: Single-dose vitamin D does not reduce nonunion rate in acute long bone fracture

Adhesive capsulitis: Pain & disability improved similarly with 20mg & 40mg corticosteroid

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