High dose vitamin D increases risk of falls and fractures in older women .
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Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial
JAMA. 2010 May 12;303(18):1815-22.2258 community-dwelling women, 70 years of age or older, were randomized to receive an annual high dosage of 500 000 IU of cholecalciferol (Vitamin D) or a placebo for 3-5 years. The purpose of this study was to compare adherence and the risk of falls and fractures between groups. At study completion, the annual Vitamin D supplement (500 000 IU) group was associated with an increased risk of falls and fractures compared to the placebo group.
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