Exhibits both analgesic and anti-inflammatory effects
Reduces prostaglandin synthesis
NSAIDs can be administered topically or orally
Oral NSAIDs are categorized as either non-selective (or traditional) NSAIDs or cyclooxygenase-2 (COX-2) inhibitors
Typically prescribed to patients after non-pharmacological approaches no longer provide symptomatic relief
With oral formulations, there are concerns regarding their long-term use due to their gastrointestinal and cardiovascular side-effects
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Hochberg MC, Martel-Pelletier J, Monfort J, et al. Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib. Annals of the rheumatic diseases. 2016;75(1):37-44.
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