Anti-inflammatory properties assumed to provide analgesic effect and decelerate joint damage
May reduce cytokine and metalloprotease expression
Experimental models show that they reduce the size, severity, and progression of both cartilage lesions and osteophyte formation
Research on corticosteroid injections in knee OA dates back to the 1950's.
Delivers high doses of synthetic corticosteroids to the joint, while minimising systemic side effects, with or without ultrasound guidance.
Available in both crystalline and non-crystalline forms, numerous formulations of corticosteroid products have been studied: betamethasone, prednisolone acetate, triamcinolone hexacetonide, methylprednisolone, hydrocortisone solution, triamcinolone acetonide, cortivazol, and methylprednisolone acetate.
Typically referred to as a second- or third-line OA treatment.
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