Intra-articular Hyaluronic Acid (IAHA)

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Mechanism of action

  • Restore the physiologic function and integrity of synovial fluid
  • Stimulation of in vivo HA synthesis
  • May enhance the synthesis of extracellular matrix proteins
  • Reduces pain and inflammation
  • Cartilage synthesis and inhibition of cartilage degradation
  • Provides joint lubrication and shock absorbency

Additional Information

  • Hyaluronic acid (HA), a natural substance abundant in the fluids of synovial joints, provides joint lubrication and shock absorbency, and acts as the backbone for the proteoglycans of the extracellular matrix
  • Approved by the U.S. Food and Drug Administration in 1997 for the treatment of knee osteoarthritis, viscosupplementation with HA has been shown to improve both pain and function in some studies
  • Pain relief is slower, but appears to last longer compared to other treatment options
  • There are many viscosupplementation products that exist, which differ in characteristics such as molecular weight, dosing, and method of preparation
  • HA can be isolated from different sources, such as rooster comb, bacterial fermentation with or without biochemical modifications


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