RESEARCH
Reproducibility in Science: a Crisis in Confidence ?
The scientific community is facing a growing crisis in reproducibility, with studies across disciplines—including cancer biology and clinical research—failing to replicate. Contributing factors include poor reporting, bias, selective publication, and weak statistical power. While clinical trials are more structured, even high-quality RCTs can overstate effects. Real-world data offers promise but reveals an “efficacy-effectiveness gap.” Improving reproducibility requires humility, transparency, and a long-term shift in research culture.
Already have an account? Log in
Unlock the Full original article
You have access to 4 more FREE articles this month.
Click below to unlock and view this original article
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
0 of 4 monthly FREE articles unlocked
