OE JOURNAL
OE Journal
Vol. 14 | Iss. 8 | April 2026 - 37 Studies
Questions This Issue Explores
In patients with severe knee osteoarthritis, is an injection platelet-rich growth factors effective in improving clinical outcomes?
Can esketamine prevent the occurrence of intra-operative, tourniquet-induced hypertension during knee surgery?
What is the efficacy of blood flow restriction training in patients recovering from ACL reconstruction?
How does the timing of dexamethasone -- peri-operatively vs. 8 hours prior to incision -- affect pain control outcomes after total knee arthroplasty?
Can the addition of instrument-assisted soft tissue mobilization to rehabilitation protocols enhance recovery after an arthroscopic rotator cuff repair?
EDITOR'S PICK 
Perioperative Intravenous Dexamethasone vs. 8 Hours Prior to Incision after Total Knee Arthroplasty
One-hundred fifty patients undergoing total knee arthroplasty (TKA) were randomized to receive intravenous dexamethasone 8 hours prior to incision or perioperatively immediately after spinal block. The primary outcome of interest was postoperative pain measured using the visual analog scale (VAS). Secondary outcomes of interest included morphine consumption, postoperative nausea and vomiting, knee circumference, C-reactive protein (CRP) levels, blood glucose levels, and infection rates. Outcomes were assessed over 48 hours postoperatively, with infection monitored for 3 months. Overall, the results of the study revealed no clinically meaningful differences in postoperative pain or inflammatory markers between groups, although small statistical differences were observed in early postoperative pain and morphine consumption. The findings suggest that both preoperative and perioperative intravenous dexamethasone provide comparable analgesic effectiveness and safety following TKA.
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