Study Summary

Ninety patients with hip fractures were randomized to receive a pericapsular nerve group (PENG) block with liposomal bupivacaine (LB), ropivacaine (R), or saline (C). The primary outcome of interest was postoperative pain, including the numeric rating scale (NRS) scores and incidence of rebound pain. Secondary outcomes included hemodynamic parameters, analgesic consumption, quadriceps function, and adverse events. Outcomes were assessed up to 72 hours postoperatively. Overall, the results of the study revealed that liposomal bupivacaine significantly reduced NRS pain scores and the incidence of rebound pain compared with both ropivacaine and saline. These findings suggest that liposomal bupivacaine PENG block provides superior and prolonged analgesia, improving postoperative recovery in elderly hip fracture patients.