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Vol:206 Issue:1 Number:2 ISSN#:2564-2537
ACE Report #14366
Ace Report Cover Osteoarthritis

Safety of Intra-articular Hyaluronic Acid for Knee Osteoarthritis: A Meta-Analysis

How to Cite

OrthoEvidence. Safety of Intra-articular Hyaluronic Acid for Knee Osteoarthritis: A Meta-Analysis. ACE Report. 2022;206(1):2. Available from:

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Safety of Intra-Articular Hyaluronic Acid for Knee Osteoarthritis: Systematic Review and Meta-Analysis of Randomized Trials Involving More than 8,000 Patients.

Cartilage . 2021 Dec;13(1_suppl):351S-363S.

Contributing Authors:
LE Miller S Bhattacharyya WR Parrish M Fredericson B Bisson RD Altman

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A meta-analysis of 35 randomized controlled trials and 8,078 patients comparing intra-articular hyaluronic acid (HA, n=4,295) to a placebo normal saline injection (n=3,783) was performed. The primary outcome of interest was the incidence of adverse events following injection. There was no significant difference in the overall rate of adverse events, the rate of serious adverse events or the rate o...

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