Efficacy of platelet-rich plasma as conservative treatment in orthopaedics: a systematic review and meta-analysis

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36 randomized controlled trials were included in his meta-analysis which examined the use of platelet rich plasma (PRP) versus varying control interventions for various soft-tissue orthopaedic injuries and conditions, predominantly elbow tendinopathy and plantar fasciitis. Pooled results among patients with elbow tendinopathy demonstrated a lack of significant difference in pain or functional measures between PRP and control groups at 3 months, but significant differences in favour of PRP groups at 6 months. In patients with plantar fasciitis, pooled results demonstrated a lack of significant difference in pain scores between PRP and control at 3 months, while 6-month results significantly favoured PRP groups. When outcome on the AOFAS functional score were considered, pooled results significantly favoured PRP groups at 3 and 6 months. When effects were evaluated in other pathologies, including patellar tendinopathy, subacromial impingement, and rotator cuff pathology, pain scores demonstrated no significant differences between groups treated with PRP injection and groups treated with control interventions.