Two dose investigation of the 5-HT-agonist psilocybin on relative and global cerebral blood flow
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(10):32 Neuroimage. 2017 23-Feb;():. 10.1016/j.neuroimage.2017.07.020What this means for my practice?
Psilocybin induced increased relative CBF (rCBF) in the right frontal/temporal regions and bilaterally in the anterior insula. There was decreased rCBF in the left parietal and occipital regions along with the amygdala, globus pallidus, insula and thalamus. Compared to placebo, there was a reduction in global CBF. There was no difference between the low and high dose in their effect on CBF, contrary to the subjective effects measured. This suggests that subjective effects are not captured by CBF changes. These findings are consistent with the previous contradictory findings of increased and decreased CBF, suggesting that analysis depends on controlling for global CBF.
Study Summary
Fifty-eight healthy subjects underwent a randomized, double-blind, placebo-controlled study to test the effects of psilocybin on cerebral blood flow (CBF). All subjects received a placebo dose, and received either a low or high dose of psilocybin. CBF was measured using pseudo-continuous arterial spin labelling (pCASL) fMRI, with and without an adjustment for global CBF (gCBF). With the gCBF adjustment, there was increased relative CBF (rCBF) in the right hemispheric frontal/temporal regions and bilaterally in the anterior insula. There was decreased rCBF in left hemispheric parietal and temporal cortices and left subcortical regions. gCBF was decreased in frontal, temporal, parietal and occipital lobes, in the bilateral amygdalae, anterior cingulate, insula, striatal regions and hippocampi.
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