Two dose investigation of the 5-HT-agonist psilocybin on relative and global cerebral blood flow .
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Two dose investigation of the 5-HT-agonist psilocybin on relative and global cerebral blood flow
Neuroimage. 2017 23-Feb;():. 10.1016/j.neuroimage.2017.07.020Fifty-eight healthy subjects underwent a randomized, double-blind, placebo-controlled study to test the effects of psilocybin on cerebral blood flow (CBF). All subjects received a placebo dose, and received either a low or high dose of psilocybin. CBF was measured using pseudo-continuous arterial spin labelling (pCASL) fMRI, with and without an adjustment for global CBF (gCBF). With the gCBF adjustment, there was increased relative CBF (rCBF) in the right hemispheric frontal/temporal regions and bilaterally in the anterior insula. There was decreased rCBF in left hemispheric parietal and temporal cortices and left subcortical regions. gCBF was decreased in frontal, temporal, parietal and occipital lobes, in the bilateral amygdalae, anterior cingulate, insula, striatal regions and hippocampi.
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