Tubercular spondylitis: Anterior debridement with instrumentation is safe and effective .
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2025;13(7):34 Asian Spine J. 2012 Sep;6(3):183-93. doi: 10.4184/asj.2012.6.3.183. Epub 2012 Aug 2132 patients with tuberculous spondylitis were randomized to receive anterior debridement and spinal cord decompression with anterior instrumentation or with no implant. Over 3 years, there was significantly greater improvement in local kyphosis in the instrumented group than in the no implant group. The instrumented group also demonstrated significantly less late loss of correction than the no implant group. However, there was no difference between the two groups with respect to improvement in canal stenosis and in the rate of complications.
Was the allocation sequence adequately generated?
Was allocation adequately concealed?
Blinding Treatment Providers: Was knowledge of the allocated interventions adequately prevented?
Blinding Outcome Assessors: Was knowledge of the allocated interventions adequately prevented?
Blinding Patients: Was knowledge of the allocated interventions adequately prevented?
Was loss to follow-up (missing outcome data) infrequent?
Are reports of the study free of suggestion of selective outcome reporting?
Were outcomes objective, patient-important and assessed in a manner to limit bias (ie. duplicate assessors, Independent assessors)?
Was the sample size sufficiently large to assure a balance of prognosis and sufficiently large number of outcome events?
Was investigator expertise/experience with both treatment and control techniques likely the same (ie.were criteria for surgeon participation/expertise provided)?
Oui = 1
Incertain = 0,5
Non pertinent = 0
Non = 0
L'évaluation des critères de rapport permet d'évaluer la transparence avec laquelle les auteurs rapportent les caractéristiques méthodologiques et les caractéristiques de l'essai dans la publication. L'évaluation est divisée en cinq catégories qui sont présentées ci-dessous.
2/4
Randomization
3/4
Outcome Measurements
2/4
Inclusion / Exclusion
4/4
Therapy Description
2/4
Statistics
Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbé KA. J Clin Epidemiol. 1992;45:255-65
L'indice de fragilité est un outil qui aide à l'interprétation des résultats significatifs, en fournissant une mesure de la force d'un résultat. L'indice de fragilité représente le nombre d'événements consécutifs qui doivent être ajoutés à un résultat dichotomique pour que le résultat ne soit plus significatif. Un petit nombre représente un résultat plus faible et un grand nombre un résultat plus fort.
Pourquoi cette étude était-elle nécessaire maintenant ?
There are various methods of treatment for tuberculous spondylitis, including chemotherapy and surgery. Of the existing surgical treatments, the most popular involves anterior debridement, strut grafting and instrumentation. While anterior debridement has been determined to be superior to posterior debridement due to the fact that it reduces bleeding and fusion of spinal levels, it is also associated with a few disadvantages. These include concerns that there may not be sufficient room for the insertion of anterior implants and the danger that vessels in the thoracic spine may be impaled. This study aimed to evaluate the effectiveness of anterior debridement, autofibular strut grafting with anterior instumentation compared with the same technique without instrumentation in patients with tuberculous spondylitis.
Quelle était la principale question de recherche ?
Is anterior debridement, autofibular strut grafting with anterior instrumentation more effective than the same procedure without instrumentation with regard to degree of local kyphosis, loss of correction, and canal stenosis improvement in patients with tuberculous spondylitis assessed over 3 years?
- There was no difference between the two groups with respect to improvement in canal stenosis (group 1: 39.98%, group 2: 34.8%; p=0.367)
- Group 1 demonstrated significantly greater improvement in local kyphosis (percentage correction: 72.02%, mean: 24.2 degrees) than group 2 (19.42%, mean: 6.1 degrees) (p<0.001)
- At 3 years, there was significantly less late loss of correction in group 1 (1.7 degrees) than in group 2 (6.7 degrees) (p=0.01)
- There were zero occurrences in both groups of wound infection, new discharging sinuses, and recurrences of the disease in the spine
De quoi dois-je me souvenir en priorité ?
The results indicated that anterior debridement, decompression of the spinal cord and autofibular strut grafting with anterior instrumentation is more effective than the same procedure without instrumentation in regards to preventing late loss of correction at 3 years, improving local kyphosis immediately post-operatively, and improving canal stenosis.
Comment cela affectera-t-il les soins prodigués à mes patients ?
Anterior debridement, decompression of the spinal cord and autofibular strut grafting with anterior instrumentation appears to be safe and effective for patients with tuberculous spondylitis.
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