Topographic pharmaco-EEG mapping of the effects of the South American psychoactive beverage ayahuasca in healthy volunteers
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(12):48 Br J Clin Pharmacol. 2002 23-Feb;():. 10.1046/j.1365-2125.2002.01609.xWhat this means for my practice?
Ayahuasca resulted in changes in brain activity, names a reduction in absolute power for total power and theta power, and a relative power decrease in the delta and theta bands, with a relative power increase in the beta band. Larger studies are warranted to replicate the findings of this study.
Study Summary
In a randomized controlled, double-blind, crossover study, 18 healthy volunteers were administered 0.6 mg DMT/kg or 0.85 mg DMT/kg of ayahuasca on separate testing days. Participants were evaluated on the Hallucinogen Rating Scale (HRS) and had 19-lead EEG recordings taken from baseline to 8 hours after administration. An absolute power decrease in all frequency bands was seen, most prominently in the theta band. Relative power decreased in the delta and theta band, and increased in the beta band. A significant, dose dependent increase in all subscales of the HRS was seen.
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