The administration of psilocybin to healthy, hallucinogen-experienced volunteers in a mock-functional magnetic resonance imaging environment: a preliminary investigation of tolerability

研究概要

Nine healthy, hallucinogen-experienced participants received a dose of intravenous psilocybin while in a mock MRI environment in order to determine tolerability. Three patients received an intravenous 1.5 mg dose of psilocybin and six patients received an intravenous 2 mg dose. A number of drug effects were rated on a 0-10 numeric rating scale in order to determine tolerability, as well as the 5-Dimension Altered States of Consciousness Rating Scale (5-D ASC). No significant difference was seen between doses on any outcome measures, and the psilocybin was well tolerated in the mock MRI environment.