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Arthroplasty

TKA: Wound infiltration with DepoFoam bupivacaine is an effective postoperative analgesia

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ARTHROPLASTY

TKA: Wound infiltration with DepoFoam bupivacaine is an effective postoperative analgesia .

This report has been verified by one or more authors of the original publication.

A randomized, double-blind, dose-ranging study comparing wound infiltration of DepoFoam bupivacaine, an extended-release liposomal bupivacaine, to bupivacaine HCl for postsurgical analgesia in total knee arthroplasty

Knee. 2012 Oct;19(5):530-6. doi: 10.1016/j.knee.2011.12.004. Epub 2012 Jan 28

Contributing Authors

K Bramlett E Onel ER Viscusi K Jones

144 patients who were undergoing primary unilateral total knee arthroplasty (TKA) were randomized to receive wound infiltration with DepoFoam bupivacaine (133 mg, 266 mg, 399 mg or 532 mg) or bupivacaine HCl with epinephrine. Over 5 days, the DepoFoam bupivacaine groups had significantly lower pain scores at rest than the bupivacaine HCl group at several time periods. On day 5, the cumulative pain score at rest was significantly lower in the DepoFoam 532 mg group than in the bupivacaine HCl group. On day 8, the blinded care provider was also significantly more satisfied with the DepoFoam 532 mg group than with the bupivacaine HCl group. There were no other significant differences between the groups.

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