Bupivacaine provides better post-operative pain relief in comparison to placebo .
Three-in-one nerve block with different concentrations of bupivacaine in total knee arthroplasty: randomized, placebo-controlled, double-blind trial
J Arthroplasty. 2012 May;27(5):673-8.e1. Epub 2011 Sep 23105 patients scheduled to undergo unilateral total knee arthroplasty were randomized to receive either a low dose or a high dose of bupivacaine or a placebo. Results from early post-operative follow-up indicated that patients who received placebo were three times as likely to experience pain. However, this difference between the three groups disappeared at 1 day post-operative follow-up. Additionally, no significant differences between the two groups were found in regards to post-operative nausea or sedation.
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