TKA: No effect of fibrin sealant on reducing blood loss and functional recovery .
No effect of fibrin sealant on drain output or functional recovery following simultaneous bilateral total knee arthroplasty
Acta Orthop. 2013 Apr;84(2):153-8. doi: 10.3109/17453674.2013.769082. Epub 2013 Jan 2524 patients (48 knees) undergoing simultaneous bilateral total knee arthroplasty (TKA) had their knees 1:1 randomized to receive an intraoperative application of either fibrin sealant or saline. The purpose was to determine the adjuvant effect of fibrin sealant on postoperative blood loss in patients already treated with preoperative tranexamic acid and tourniquet use. Blood loss was calculated 24 hours following surgery, and patients were assessed for functional recovery up to 21 days postoperatively. The findings indicated that there was no decrease in blood loss in knees treated with fibrin sealant, and that pain, swelling, range of motion, and isokinetic strength was similar between knees, regardless of the application of fibrin sealant or saline.
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