The Safety & Efficacy of Patient-Specific Instrumentation for Total Knee Replacement .
The efficacy and safety of patient-specific instrumentation in primary total knee replacement: a systematic review and meta-analysis.
Expert Rev Med Devices . 2023 Mar;20(3):245-252.Forty-three randomized controlled trials including 3,703 patients with primary total knee arthroplasty were included in this systematic review and meta-analysis comparing patient-specific instrumentation (PSI) vs. non-PSI. Pooled outcomes of interest included patient-reported outcome measures (PROMS), clinical outcome scores, peri-operative blood loss, revision rates, and complication rates. The results indicated no clinically relevant differences in efficacy or safety between the PSI and non-PSI groups. There was considerable heterogeneity, with earlier studies showing a positive effect for PSI, while later studies showed the opposite. The study concludes that PSI does not provide clinically significant benefits over conventional instrumentation in primary TKA.
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