Meta-analysis of cause of death following total joint replacement using different thromboprophylaxis regimens

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この研究はハイインパクトの可能性があります。 OEのAI駆動型ハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文が持つ可能性の高い影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することが可能になり、読者は将来の診療を形成する可能性が最も高い論文に集中することができます。

The findings of 70 publications, focusing on total joint replacement (TJR) which used some form of thromboprophylaxis, were combined to assess the effect of throboprophylaxis on mortality and proportion of deaths due to a known or suspected pulmonary embolism (PE) in modern TJR. 99441 patients were categorized into 7 groups based on the type of throboprophylaxis. Death occurred in 373 of the patients analysed; these deaths were then grouped by cause, including cardiopulmonary (excluding PE), pulmonary embolism (PE), bleeding, CNS, gastrointestinal and other. Results indicated that there was a very low mortality rate, regardless of thromboprophylaxis in TJR. The use of potent anti-coagulants (PA) did not reduce the mortality rate or the proportion of deaths due to a known or suspected PE and called in to question their routine use following TJR.