Changes in Prescription Pain Medication and Intra-Articular Corticosteroid Utilization after Intra-Articular Bioengineered Hyaluronic Acid in Routine Clinical Practice
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2021;9(23):11 Changes in Prescription Pain Medication and Intra-Articular Corticosteroid Utilization after Intra-Articular Bio-fermentation Derived Hyaluronic Acid Use in Patients Undergoing Multimodal Pain ManagementWhat this means for my practice?
According to this database study, patients receiving Bio-HA significantly reduced their prescription pain medication and intra-articular corticosteroid utilization. Further high-quality randomized controlled trials are warranted to confirm the results of the current study.
Study Summary
Commercial and Medicare Supplemental claims data was queried and identified patients with 13,999 patients with knee osteoarthritis who had utilized bio-fermentation derived high molecular weight hyaluronic acid (Bio-HA) as a part of multimodal therapy (any combination of corticosteroid injection, opioids and non-opioid pain medications). The primary outcome of interest was multimodal therapy utilization before and after Bio-HA injections. The number of opioid prescriptions filled decreased significantly after Bio-HA injections. Of patients who continued to fill opioid prescriptions, the number of prescriptions per month decreased significantly. Similarly, the number of 'opioid days' supplied decreased after Bio-HA injections and the number of prescription pain medication-free days increased. Patients underwent intra-articular corticosteroid injections following Bio-HA injections.
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