The experimental effects of psilocybin on symptoms of anxiety and depression: A meta-analysis
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(10):12 Psychiatry Res. 2020 14-Feb;()What this means for my practice?
This meta-analysis showed that post-treatment and six-month follow-up within-group effects showed large reductions in anxiety and depression symptoms, indicating a promising outlook on the efficacy of psilocybin. However, besides the small number of studies analyzed, there was high between-study heterogeneity and a high risk of bias in various domains. Lastly, the studies all contained smaller sample sizes.
Study Summary
Four distinct trials (a single-group design, and three randomized, placebo-controlled cross-over designs) were examined in this meta-analysis. These trials examined the effects of both psilocybin and behavioural interventions in patients with elevated anxiety and depression. Outcomes included a pre-post within-group effect, a between-groups effect, and a pre to follow-up effect. There were large and statistically significant within-group pre-post effects and pre-follow-up effects on anxiety and depression across the four trials.
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