Preliminary Report on the Effects of a Low Dose of LSD on Resting-State Amygdala Functional Connectivity
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(10):18 Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 14-Feb;():. 10.1016/j.bpsc.2019.12.007What this means for my practice?
A small dose of LSD impacts amygdala connectivity. The increase in connectivity between the amygdala and the middle frontal gyrus was positively correlated with positive mood. The changes seen in amygdala connectivity are consistent with previous research using higher doses of LSD and other psychedelics. The results are limited by the use of a single LSD dose, when microdosing of LSD requires repeated doses. Additionally, the sample consisted of only healthy subjects.
Study Summary
Twenty healthy subjects underwent a within-subjects, double-blind, randomized trial to examine the effects of one low 'microdose' of LSD (13 micrograms) on resting-state functional connectivity and cerebral blood flow. Subjects received either the placebo or LSD dose, and participated in two fMRI scanning sessions seven days apart. Amygdala and thalamic connectivity were analyzed and mood questionnaires were collected. The LSD microdose increased amygdala seed-based connectivity with the right angular gyrus, right middle frontal gyrus and the cerebellum, while decreasing amygdala connectivity with the left and right postcentral gyrus and the superior temporal gyrus.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
Are you affiliated with one of our partner associations?
Click here to gain complimentary access as part your association member benefits!
0 of 4 monthly FREE articles unlocked
