Preliminary Report on the Effects of a Low Dose of LSD on Resting-State Amygdala Functional Connectivity
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OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(10):18 Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 14-Feb;():. 10.1016/j.bpsc.2019.12.007Study Summary
Twenty healthy subjects underwent a within-subjects, double-blind, randomized trial to examine the effects of one low 'microdose' of LSD (13 micrograms) on resting-state functional connectivity and cerebral blood flow. Subjects received either the placebo or LSD dose, and participated in two fMRI scanning sessions seven days apart. Amygdala and thalamic connectivity were analyzed and mood questionnaires were collected. The LSD microdose increased amygdala seed-based connectivity with the right angular gyrus, right middle frontal gyrus and the cerebellum, while decreasing amygdala connectivity with the left and right postcentral gyrus and the superior temporal gyrus.
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