Single-shot dose and continuous infusion of TXA have similar efficacy in primary TKA .
This report has been verified
by one or more authors of the
original publication.
Single dose intravenous tranexamic acid as effective as continuous infusion in primary total knee arthroplasty: a randomised clinical trial
Arch Orthop Trauma Surg. 2015 Apr;135(4):465-71106 patients undergoing total knee arthroplasty were randomized to receive either a 30mg/kg bolus dose of tranexamic acid (TXA), or 10mg/kg dose TXA plus 2mg/kg/h continuous infusion postoperatively for 20 hours. The purpose of this study was to compare blood loss within the first week of surgery, as well as complications and clinical outcomes within the first year of surgery. The findings illustrated no significant differences between groups for any of the measured outcomes. Additionally, no venous thromboembolic events were noted in any patient of either group.
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