Four studies (two randomized controlled trials [RCTs] and two non-RCT comparative trials) were included in this systematic review and meta-analysis to compare outcomes following anterior cervical discectomy and fusion with either a polyetheretherketon (PEEK) cage or a titanium cage. Pooled results demonstrated no significant differences in the rate of successful fusion, clinical outcome on the Odom's criteria measure, final segmental angle, or loss in segmental correction over follow-up between groups. A significantly higher incidence of cage migration was noted with titanium cages. The results from this meta-analysis were based on data from only four studies, only two of which were RCTs. This highlights the need for additional RCTs to verify the results of this meta-analysis and strengthen the current body of literature comparing PEEK and titanium cages in ACDF procedures.