Similar effect observed with PRP alone or in combination with LMW- or HMW-HA in knee OA treatment .
A study assessing intra-articular PRP vs PRP with HMW HA vs PRP with LMW HA in early knee osteoarthritis
J Arthrosc Joint Surg. 2017;4(2):65-7151 patients with knee osteoarthritis were randomized to intraarticular therapy with either platelet-rich plasma alone, platelet-rich plasma combined with low-molecular-weight hyaluronic acid, or platelet-rich plasma combined with high-molecular-weight hyaluronic acid. Patients were assessed for outcome on the International Knee Documentation Committee (IKDC) score and visual analog scale (VAS) pain after 6 weeks and 6 months. Results demonstrated no significant between-groups differences between any two of the three groups for either outcome measure at 6 weeks or 6 months.
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