Greater pain and functional improvement with highly- versus moderately-crosslinked HA in knee OA .
A pilot study to compare two different hyaluronic acid compounds for treatment of knee osteoarthritis.
Int J Immunopathol Pharmacol. 2012 Oct-Dec;25(4):1093-820 patients with bilateral knee osteoarthritis were administered two intraarticular injections of Variofill in the right knee and two intraarticular injections of Hylan G-F 20 in the left knee. Patients were assessed for treatment response on a Visual Analog Scale for pain and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) after 3 and 6 months. Comparative efficacy was assessed using percent improvement from baseline after 6 months. Results demonstrated significantly greater improvement for VAS pain, WOMAC Pain, and WOMAC Function scores in the Variofill group compared to the Hylan G-F 20 group, with no significant differences between groups in improvement in WOMAC Stiffness.
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