65 patients scheduled for a unilateral total knee arthroplasty were randomized to receive a continuous femoral nerve block (FNB) with bupivacaine or a peri-articular injection with liposomal bupivacaine (EXPAREL). The primary outcome of interest was the pain intensity during maximal knee flexion, specifically at 24 hours. Secondary outcomes included pain intensity at rest, during movement and during axial load, knee flexion, proportion of patients requiring knee immobilization during physical therapy, time to first use of patient controlled analgesia, narcotic consumption, post-operative nausea and vomiting, patient satisfaction, as well as peak and mean serum bupivacaine concentrations. Follow up was performed up to 72 hours post-operation. The results from this study found no significant differences in pain scores at rest, during motion, or during maximal flexion at all time points. Pain scores were significantly higher during axial load at 24 hours in the liposomal bupivacaine group. Time to first use of patient controlled analgesia, as well as the proportion of patients requiring knee immobilization during physical therapy at 24 hours, was significantly favourable in the liposomal bupivacaine group. Lastly, knee flexion range of motion at 48 hours was significantly favourable in the continuous femoral nerve block group. Otherwise, there were no significant differences between groups in the remaining outcomes.