Short-term pain and function benefit with HA for knee OA in trials with low risk of bias .
Hyaluronan for knee osteoarthritis: an updated meta-analysis of trials with low risk of bias
RMD Open. 2015 May 14;1(1):e000071Eight double-blind, placebo controlled randomized trials were included in this meta-analysis assessing efficacy outcomes of intra-articular hyaluronic acid injections in the treatment of knee osteoarthritis. Data on pain and functional outcome measures were extracted and pooled. Results demonstrated small but statistically significant differences between IAHA and IA placebo injections in both pain and functional outcome at 3 months. GRADE assessment indicated "moderate" quality of evidence related to both outcomes.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
0 of 4 monthly FREE articles unlocked
