Safety, tolerability, and efficacy of psilocybin in patients with obsessive-compulsive disorder .
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Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder
J Clin Psychiatry. 2006 11-Apr;():. 10.4088/jcp.v67n1110Nine patients with DSM-IV-define obsessive-compulsive disorder (OCD) received up to 4 single exposures to psilocybin at low (100 ug/kg), medium (200 ug/kg), high (300 ug/kg) and negligible (placebo, 25 ug/kg) doses in a double blind, randomized fashion. Symptoms of OCD were assessed using the Yale-Brown Obsessive Compulsive Scale (YBOCS) and a visual analog scale of overall obsessive-compulsive symptom severity were assessed. Patients at all doses saw a reduction on the mean YBOCS score for all doses after the administration of psilocybin, but no significant difference was seen between any of the doses in the reduction in YBOCS. No significant effects were seen on the visual analog scale rating of OCD symptoms.
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