Safety and effcacy of remimazolam tosilate for sedation during combined spinal-epidural anesthesia for orthopedic procedures: a randomized controlled trial.
OrthoEvidence Journal (OE Journal) - ACE Report
Epub Ahead of Print
BMC Anesthesiol. 2024 01-Feb;():. 10.1186/s12871-024-02451-7What this means for my practice?
Remimazolam provides faster onset, quicker recovery, and fewer adverse events compared with dexmedetomidine when used for sedation during orthopaedic surgery under combined spinal-epidural anesthesia. These findings support remimazolam as an effective alternative sedative that may improve perioperative efficiency and patient safety. Key limitations include the single-centre design and lack of postoperative follow-up beyond the intraoperative period.
Study Summary
Eighty patients undergoing orthopaedic surgery with combined spinal-epidural anesthesia were randomized to receive remimazolam or dexmedetomidine. The outcomes of interest were time to achieve adequate sedation, recovery time, intraoperative vital signs, incidence of adverse events, and patient satisfaction with sedation. Outcomes were assessed intraoperatively from baseline through recovery. Overall, the results of the study revealed that remimazolam resulted in faster onset of sedation, quicker recovery, fewer adverse events, and similar hemodynamic stability compared with dexmedetomidine. These findings suggest remimazolam is a safe and effective alternative sedative for orthopaedic surgery under combined spinal-epidural anesthesia.
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