ملخص الدراسة

Eighty patients undergoing orthopaedic surgery with combined spinal-epidural anesthesia were randomized to receive remimazolam or dexmedetomidine. The outcomes of interest were time to achieve adequate sedation, recovery time, intraoperative vital signs, incidence of adverse events, and patient satisfaction with sedation. Outcomes were assessed intraoperatively from baseline through recovery. Overall, the results of the study revealed that remimazolam resulted in faster onset of sedation, quicker recovery, fewer adverse events, and similar hemodynamic stability compared with dexmedetomidine. These findings suggest remimazolam is a safe and effective alternative sedative for orthopaedic surgery under combined spinal-epidural anesthesia.